What Is THC (Delta-9-Tetrahydrocannabinol)?دلتا-9-تتراهیدروکانابینول چیست

What Is THC (Delta-9-Tetrahydrocannabinol)?


General Reference (not clearly pro or con)
The Institute of Medicine published in its Mar. 1999 report titled "Marijuana and Medicine: Assessing the Science Base":
"Delta-9-tetrahydrocannabinol (Delta-9-THC) is the primary psychoactive ingredient [in marijuana]; depending on the particular plant, either THC or cannabidiol is the most abundant cannabinoid in marijuana. ... 

[T]he effects of THC are included among the effects of marijuana, but not all the effects of marijuana are necessarily due to THC. ... Cannabinoids are produced in epidermal glands on the leaves (especially the upper ones), stems, and the bracts that support the flowers of the marijuana plant. Although the flower itself has no epidermal glands, it has the highest cannabinoid content anywhere on the plant, probably because of the accumulation of resin secreted by the supporting bracteole (the small leaf-like part below the flower). ... 

Delta-9-THC and Delta-8-THC are the only compounds in the marijuana plant that produce all the psychoactive effects of marijuana. Because Delta-9-THC is much more abundant than Delta-8-THC, the psychoactivity of marijuana has been attributed largely to the effects of Delta-9-THC. ... 
 
THC molecule, U.S. Institute of Medicine, March, 1999
Marijuana and Medicine: Assessing the Science Base 

All recent studies have indicated that the behavioral effects of THC are receptor mediated. Neurons in the brain are activated when a compound binds to its receptor, which is a protein typically located on the cell surface. Thus, THC will exert its effects only after binding to its receptor. ... Binding to a receptor triggers an event or a series of events in the cell that results in a change in the cell's activity, its gene regulation, or the signals that it sends to neighboring cells."

Mar. 1999 - Institute of Medicine 



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